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10th
INTERNATIONAL CONGRESS and
15th
NATIONAL of CLINICAL PSYCHOLOGY MONASTERIO
SAN MARTÍN PINARIO
SANTIAGO DE COMPOSTELA (SPAIN) 16-19 NOVEMBER, 2017 |
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Jürgen Margraf Mental Health Research and Treatment Center, Ruhr-Universität Bochum ALEMANIA |
 English |
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Jürgen Margraf studied
psychology, sociology and physiology in
Germany and Belgium. After a research
scholarship in Psychiatry and Behavioral
Sciences at Stanford University he completed
his PhD at the University of Tübingen in 1986
and subsequently held professorships in
Berlin, Dresden, Basel and Bochum. In 2009 he
was the first psychologist to be awarded an
Alexander von Humboldt-Professorship,
Germany´s most highly endowed scientific
award. His work focuses on the interplay
between psychological, biological and social
factors in mental health, using a combination
of etiological, epidemiological and
intervention research strategies and leading
to some 500 publications. He is member of the
Leopoldina - German National Academy of
Science, member of the Academia Europaea and
Fellow of the Association for Psychological
Science as well as past president of the
European Association for Behavioural and
Cognitive The¬rapies (EABCT), the German
National Scientific Council on Psychotherapy
and the German Society of Psychology.
CONFERENCE ABSTRACT Enhancing Exposure and
Extinction (Triple E)
Exposure therapy is a major
success story in mental health with extinction
learning as a core active ingredient.
Systematically enhancing exposure and extinction
offers a scientifically promising and ethically
justified pathway to a mechanistic understanding
of lasting therapeutic change. Our research
program combines laboratory experiments,
clinical and long-term follow-up studies to
elucidate behavioral and pharmacological
augmentation as well as psychological and
biological mechanisms. Cortisol, sleep and
increased self-efficacy systematically enhance
outcomes, underscoring the relevance of learning
and memory mechanisms. Our new large-group
exposure protocol allows the highly standardized
simultaneous treatment of up to 80 patients in a
single session. Using this, we were able to show
that genetic variation of the serotonin
transporter gene is associated with differential
stability of inhibitory learning and long-term
therapeutic outcome, potentially reflecting
heightened susceptibility to context-related
fear renewal in S-allele carriers. Together,
augmentation, follow-up and therapy genetic
findings have important clinical and research
implications.
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